Exchange ratio of stock options for each new stock option Number of new stock options issuable upon conversion for each stock option currently held by employees. David H. Mack, Ph.D. [Member] Deepika Jalota, Pharm.D. [Member] Michael Carulli [Member] Robert Ticktin [Member] Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period