Exchange ratio of stock options for each new stock option Number of new stock options issuable upon conversion for each stock option currently held by employees. Share Based Compensation Arrangement by Share Based Payment Award Plan Modification Option Exchange Ratio This element represents the ratio used in an option exchange program under the company’s share-based compensation arrangement, specifying the number of old options needed to receive new options. David H. Mack, Ph.D. [Member] Deepika Jalota, Pharm.D. [Member] Michael Carulli [Member] Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period